Subtenolin. An Antibiotic from Bacillus subtilis . I. Bacteriologic Properties

Abstract

Summary and Conclusions

1. An antibiotic, tentatively designated subtenolin, was isolated from a strain of Bacillus subtilis.

2. Although the antagonist displays its greatest activity against staphylococci, the growth of certain gram-positive as well as gram-negative organisms is inhibited.

3. The growth of Mycobacterium tuberculosis is partially inhibited by subtenolin.

4. Subtenolin activity has been detected in urines recovered from intraperitoneally inoculated mice.

5. Acute toxicity studies show that the LD₅₀ of subtenolin for mice inoculated intraperitoneally is 30 to 60 mg (30,000-60,000 units).