Abstract
Summary and Conclusions
The antibiotic Chloromycetin has been found to be only moderately bacteriostatic for virulent human type tubercle bacilli in vitro as compared with streptomycin or para-aminosalicylic acid. The majority of 19 human type strains studied were completely inhibited in their growth by between 6.25 and 12.5 micrograms or more of the drug in the presence of serum. One bovine strain was equally sensitive. This degree of bacteriostatic activity was not markedly affected by the number of tubercle bacilli present nor was the bacteriostatic activity of para-aminosalicylic acid or streptomycin enhanced by the addition of Chloromycetin.
When administered subcutaneously, Chloromycetin has been shown to be ineffective, whereas, when admixed with the diet in concentrations of 0.5 and 0.25%, it was slightly effective for the suppression of experimental murine tuberculosis.
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