Therapeutic Effectiveness of Single and Divided Doses of Penicillin in a Streptococcal Infection in Mice

Abstract

Conclusion

From 4 to 8 times as much penicillin was needed for oral, as for subcutaneous administration, to obtain the same degree of therapeutic effect in a streptococcal infection in mice.

In this infection, the administration of daily penicillin dosage in a series of small equally spaced doses was not more effective than giving an equivalent amount of drug in 1 or 2 doses per day.