The Lymphoid Tissue and Antibody Formation

Abstract

Summary

Adrenalectomized rabbits with hypertrophy of the lymphoid tissues produce antibodies in amounts far in excess of that produced by intact animals. this is evident not only by definite reactions in higher dilution but by the more masive precipitate in low dilutions. The prevention of the lymphoid hypertrophy by administration of adrenal cortical hormones does not reduce the amount of antibodies in the sera. This is probably due to the disruptive action of the hormone on the lymphocyte with a more rapid release of the immune globulin than would normally take place.