Abstract
Summary
The oral administration of 4′-carboxyphenylmethane-sulfonanilide(caron-amide) was found to enhance considerably the therapeutic effectiveness of intramuscularly-administered penicillin in mice experimentally infected with either Type I pneu-mococci or E. typhosa. This enhancement was 6- to 16-fold in the case of the pneu-mococcus experiments and approximately 4-fold for E. typhosa. These effects may be explained on the basis of the higher and more prolonged plasma penicillin concentrations when caronamide is administered, and do not indicate synergy between caronamide and penicillin. The significance of these observations in relation to penicillin therapy is discussed.
Get full access to this article
View all access options for this article.