Human Infection with Rift Valley Fever Virus and Immunity Twelve Years After Single Attack. ∗

Abstract

Summary

1. Accidental human laboratory infection with a strain of Rift Valley Fever virus which had undergone at least about 300 intracerebral passages in mice, indicated that no modification in its pathogenicity for man resulted from this mode of passage.

2. The virus was recovered from the blood 10 hours after the first appearance of headache but titration revealed that the virus content was very low-only 666 LD₅₀ per cc of serum. Four days after onset, no virus was detected in the blood, but neutralizing antibodies (index of 50) were already present and in the next 10 days increased to yield an index of at least 1,585,000.

3. Neutralizing antibodies for Rift Valley Fever virus (index of 3,160) were found 12 years after a single attack in the serum of an individual who had no further exposure to the virus during the intervening years.