Abstract
Conclusions
1. Ulcers in the forestomach were induced in rats: (a) Recovering from vitamin A-deficiency with 2, 30, or 300 units vit. A daily, (b) Recovering from a vit. B6 deficiency with suboptimal amounts (1, 2, or 4 γ daily) of pyridoxine. (c) Recovering from an essential fatty acid deficiency with 20 mg of linoleate daily.
2. Deficiencies of these 3 essentials did not, in themselves, result in lesions. The ulcers occurred only during the curative period in which the specific nutrient was fed.
3. α-Tocopherol fed daily to the rats during the cure of the specific deficiency gave complete protection. γ-Tocopherol orally was also effective, but a-tocopheryl phosphate injected was not.
4. The amount of fat in the diet was related to the incidence of stomach ulcers in the vitamin A experiments. Ten per cent gave good protection. Five per cent allowed moderately severe lesions, which were preventable by tocopherol. Fat-low diets gave very severe lesions not preventable by the level of tocopherol fed, 0.5 mg daily.
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