Abstract
Summary
Over 400 tests were made in 210 animals with 23 different agents on the threshold for electrical convulsions, chiefly in white rats; a few in rabbits. Of 3 new hydantoins studied, di-isobutyl-hydantoin was the most promising, being somewhat comparable to sodium diphenylhydantoin in high doses. Among the ineffective agents were 4 drugs of the curare group, alleged central depressants, and 5 different dyes, including hematoxylin and vital red, alleged antiepileptic agents.
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