Studies of the Thoracic Duct Lymph in Experimental Liver Injury in Dogs

Abstract

Summary

A method is described that allows collection of thoracic duct lymph over, a period of dayi. the lymph circulating through it. natural channel during the intervals in which it is not being collected. Liver injury caused by either CCl₄ or MnCl₂ nere qualitatively comparable in dogs, the change; being more marked with the latter.

In elevation of the alkaline phosphatase activity and bilirubin content of both blood and thoracic duct lymph were noted. The main componeat of the bilirubin was the 1′ or prompt reacting type. 9 , 10 The behavior of the injected bromsulfalein ma comparable tothat of the 32-hour stage, following common bile duct ligation. No significant changeswere observed as regards the bile acids, total cholesterol or cholester esters.