Abstract
Summary
The antifibrillating activity of a series of tertiary bases with a carbon skeleton related to the possible chemical structure of α-fagarine has been assayed in rabbits. Eight of them were derivatives of methyl-dibenzyl-amine by addition of either methox-ylic or dioxomethylenic groups to the aromatic nuclei; the others, also chemically related, were ethyl-dibenzyl-amine, methyl-benzyl-anisidine and methyl-benzyl-phenetyl-amine. Their effects were compared with those of quinidine and α-fagarine, tested under the same conditions.
All of them showed antifibrillating activity. The maximal effect, however, was given by a-fagarine. The addition of methoxylic and dioximethylenic groups modified the activity of methyl-dibenzyl-amine, the former enhancing the effect against fibrillation of the ventricles and the latter enhancing the effect against auricular fibrillation.
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