Abstract
Summary and Conclusions
Rat peritoneum reacts to the presence of various acid-colloidal pigments by thickening, primarily due to the accumulation of sub-mesothelial histiocytes and macrophages. The surface mesothelial cells may round up, and separate from their connective tissue bed. Pigment-filled macrophages escape through these denuded regions and pass into the peritoneal cavity; the same cells are sometimes seen to insinuate themselves between adjacent intact mesothelial cells as well. Localized collections of free cells may appear in the peritoneum of the mesentery and omentum; when large, these masses typically show necrotic centers.
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