Abstract
Summary
The thrombogenic activity of some soaps and synthetic detergents was compared by injecting their solutions under standardized conditions into the tail vein of mice. Sodium tetradecyl sulfate (2-methyl-7-ethyl-undecyl sulfate-4) and Aerosol OT (di-2-ethylhexyl sodium sulfosuccinate) were found to be more potent agents than the soap solutions generally used to sclerose veins. Alkyl sulfates and sulfonates containing large branched chain hydrophobic residues were found to produce thrombus more readily than their straight chain isomers. Sodium tetradecyl sulfate produced less tissue reaction than sodium ricinoleate or sodium morrhuate. Its toxicity was not significantly greater than that of the soap solutions studied.
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