Abstract
Summary
A modified ferret-passage distemper virus exhibits an interference, or cell-blockade, phenomenon with respect to a virulent distemper virus in foxes. If the virulent virus is inoculated intranasally, as occurs in a natural infection, interference occurs when the modified virus is inoculated at the same time as, or after, the virulent virus. If the virulent virus is inoculated intramuscularly, the virulent infection can be blocked off by the modified virus only if the modified virus is given before, or at the same time as, the virulent virus. After an intramuscular injection of a virulent virus, any effect of the modified virus is in turn blocked off. The results appear to be determined by the virus that seeds the most tissue cells first. In the case of intranasal inoculation, the distemperoid virus seems to have a definite therapeutic effect during the incubation period and in the stage of early symptoms.
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