Abstract
Summary
The variations of some chemical constituents in the urine of rats receiving dl-serine have been studied quantitatively. The results have been compared with those of similar experiments in which dl-alanine has been given. In the serine groups, a significant proportion of the administered amino acid is excreted in the urine. In addition, in the first few days of serine administration, the urine contained protein and sugar, and the amounts of bisulfite-binding and of reducing substances were elevated. The presence of ethanolamine in later periods of the experiment appears probable. None of these changes was observed in the urine of animals receiving dl-alanine.
The possible bearing of these results to the injurious action of serine is discussed. At any rate, the present data confirm and extend the indication of chemical changes in the urine which are as typical as the other clinical and pathological alterations found in rats receiving dl-serine.
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