Abstract
Summary
A transient period of hypercholesterolemia and hyperlipemia may accompany the early stage of severe diabetes mel-litus in rabbits following the injection of alloxan. It occurred in varying degrees in many rabbits that survived with persistent diabetes and always occurred if the diabetes was severe enough to cause death. A dosage of 50 mg/kg of alloxan failed to cause hyperlipemia or hypercholesterolemia, 100 mg/kg produced it in one of 3 rabbits, while 125 mg/kg was effective in 29 of 32 animals. Lesions were found in the adrenal cortices of 12 of 25 animals dying after receiving 125 mg/kg of alloxan.
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