Non-Availability of Fecal Thiamine in Thiamine Deficiency

Abstract

Summary

Rats maintained on a thiamine-deficient diet excreted essentially the same concentration of thiamine in their stools as did animals receiving 5 or 50 μg of thiamine daily. The output of feces was greatly reduced in the thiamine low group. During the later stages of the depletion the thiamine was present largely in the form of cocarboxy-lase.

The fecal thiamine of the deficient rats was not available when administered curatively by the oral route to animals which had plateaued in weight on a thiamine-low diet.