Abstract
Summary
The feeding of succinylsulfathiazole in conjunction with an egg white containing diet with or without liver, did not aggravate the signs of biotin depletion in the rat nor was the period required to produce such deficiency manifestations shortened.
When biotin was administered in conjunction with the sulfonamide ration with liver, normal growth resulted. Biotin and a “folic acid” concentrate, when fed separately as adjuncts to the diet without liver, gave only minimal growth responses. The feeding of both vitamins produced a growth response that almost equalled that observed with rats receiving the liver containing ration supplemented with biotin.
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