Abstract
Summary
Rats receiving sulfasuxidine in a purified ration exhibit a marked increase in the calcium content of the liver within 4 to 8 weeks. The increased calcium content is apparently a primary metabolic defect and not a secondary calcification following necrosis. Rats fed sulfathiazole show the same syndrome but not as consistently. The calcium of the kidney and muscle of rats fed sulfasuxidine or sulfathiazole is not increased. The altered calcium metabolism of the liver can be reversed or prevented by feeding solubilized liver for 10 to 40 days. Rats receiving sulfadiazine have an increased calcium content of the kidneys but not of liver or muscle.
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