Abstract
Summary
1. Gramine hydrochloride raises blood pressure in anesthetized cats in small doses but lowers it, with a secondary rise, in doses of 30-40 mg per kg. 2. In appropriate concentrations, gramine HCl by perfusion in frogs causes slight constriction of peripheral blood vessels. 3. Gramine HCl when perfused into the inferior vena cava of frogs decreases the amplitude and rate of heart contractions. 4. Gramine HC1 inhibits, frequently preceded by a brief stimulation, peristaltic movements of isolated rabbits' small intestines. 5. Gramine HCI contracts the isolated uteri of rabbits, guinea pigs, and Syrian hamsters. 6. Gramine HCI reduces the effect of epinephrine on blood pressure, intestinal movements, and uterine (isolated) contractions, but causes no reversal. 7. Gramine HCl in doses of 5-20 mg per kg does not alter the concentrations of blood sugar in rabbits. 8. The toxicity of gramine HCl has been determined by intravenous injection in both mice and rats, the latter being less susceptible.
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