Abstract
Summary and Conclusions
A method is described for obtaining biopsied brain tissue containing exoerythrocytic stages of Plasmodium gallinaceum throughout their course of development in individual chicks. With this method it is feasible to examine individual animals repeatedly without appreciable harm, thus making it a valuable technic for any study on exoerythrocytic schizogony. Earlier studies made from autopsies have been confirmed. In addition it has been shown that in occasional animals exoerythrocytic stages were encountered which spontaneously disappeared, although this finding is infrequent. From the standpoint of chemotherapy, it has been found that sulfadiazine will prevent the appearance of these forms. Likewise this same drug or sulfapyrazine will effect a cure and cause a disappearance of exoerythrocytic schizonts even after they have made their appearance. Quinine and atebrin have no prophylactic or curative action. Plasmochin has a questionable therapeutic effect. The implications of this study are evident if it is eventually shown that exoerythrocytic schi-zogony is an integral part of human malarial infections. However, regardless of its place in the life cycle of plasmodial infections, the fact that these forms respond so readily to some of the sulfonamide compounds and yet are totally refractory to quinine or atebrin furnish another lead in the study of malarial chemotherapy.
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