Abstract
Summary
Twenty-three senile dogs showing varying degrees of glomerular injury and at the same time a fairly diffuse change in the type of epithelium in the proximal segment of the renal nephron from a normal order of cuboidal cell to one of a flattened, less specialized type of cell when subjected to the anesthetic action of chloroform for 45 minutes fail to show, as the result of the use of this body, a reduction in the elimination of phenolsulphanephthalein, or a reduction in the reserve alkali of the blood from that value which these animals have established as their pathological normal. In a group of 29 control senile animals, with a normal urine, both chemically and microscopically, with the same order of change in the glomeruli but with, in general, a normal order of cytological structure in the proximal segment of the renal nephron when anesthetized for 45 minutes with chloroform show a marked decrease in the elimination of phenolsulphanephthalein and a reduction in the reserve alkali of the blood.
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