Abstract
Conclusion
Saliva, bile, and succus en-tericus obtained from man do not inactivate penicillin. Gastric juice destroys this antibacterial substance rapidly especially at body temperature. Hydrochloric acid, and not pepsin, is apparently responsible for this action of gastric juice.
In 2 subjects with pernicious anemia the absorption of penicillin, when administered by mouth, was greater than that observed in normal subjects.
The authors wish to thank Marjorie Jewell, Thelma Maxon, and Grace Helm for their assistance.
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