Abstract
Summary
The infusion of crystalline methemoglobin into dogs acidified with ammonium chloride is followed by a fall in the effective renal plasma flow and the glomerular filtration rate of the dog. The dog may die in uremia on the third day following the infusion. Infusions of metmyoglobin and hemoglobin into acidified animals, and of methemoglobin and hemoglobin into normal animals, fail to depress renal function. The renal lesions of acidified dogs infused with methemoglobin resemble those observed in cases of crush syndrome and black water fever.
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