Abstract
Summary
In rats on a vitamin E-deficient diet the cholesterol content of muscle was significantly increased, the total lipid less markedly. In brain tissue the cholesterol content was markedly increased, especially that of the free cholesterol, such that cholesterol esters represented about 5% of the total; in control animals this figure was 35%. These changes generally parallel those reported for rabbit tissue but are not as striking, perhaps because in grown rats dystrophy develops slowly. An understanding of these changes must await further knowledge of the functional activity of vitamin E.
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