Abstract
Numerous reports have appeared regarding the development of sulfonamide resistance by pneumococci in vitro and in vivo, and by gonococci. We have not seen a similar report regarding Shigella paradysenteriae.
In the course of our in vitro studies we have developed 2 sodium sulfathiazole resistant strains of Shigella paradysenteriae, one each of the Flexner and Sonne types. Sodium sulfathiazole was bactericidal for the parent Flexner strain in a concentration of 80 mg % and for the sulfonamide resistant sub-strain in a concentration of 600 mg %. Sodium sulfathiazole was bactericidal for the parent Sonne strain in a concentration of 300 mg % and for the sulfonamide resistant sub-strain in a concentration of 1000 mg %.
The sulfonamide resistant Flexner strain retained its virulence for white mice (1 M.F.D. being 1.0 cc of 10-5 in 3% mucin), but was non-resistant to sodium sulfathiazole in vivo. The resistant Sonne strain became non-virulent.
Further studies are planned with these parent and sulfonamide resistant strains and other sulfonamide compounds.
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