Abstract
Summary
Anoxia induced at birth invariably produced symptoms of neural damage. Transient shock, tremors, ataxia, and incoördination were not usually associated with impaired behavior or brain pathology. More than 8 min of anoxia lead to such symptoms as decerebrate states, marked ataxia, convulsions, paralysis, hyper- and hypoesthesia and somnolence, correlated in some cases with behavioral changes. Highly variable nonspecific devastation of brain and cord tissues, occasional hemorrhages, gliosis and generalized atrophy were encountered.
All experiments were controlled with healthy litter-mates and permit the conclusion that neonatal asphyxia (asphyxia pallida) may induce irreparable fortuitous destruction of large or small regions of the brain.
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