Abstract
Summary
Amounts of benzpyrene ranging between .04 γ and 4 mg dissolved in 0.5 cc of olive oil were injected subcutaneously into mice. The smallest amount producing a sarcoma was 4 γ. The data suggest a linear relationship between the logarithm of the injected dose and the average latent period of tumors, as found by Bryan and Shimkin. A similar relationship was found between dose and average length of survival of the tumor-bearing animals. When dissolved in .125 to 1 cc of oil, 400 γ of benzpyrene produced tumors in 40% or more of the mice. When dissolved in from .0625 to .015 cc of oil, the incidence of tumor production was 25% or less. No relationship was found between average latent period and volume of injection. A technic is described for the study of the rate of re-sorption of benzpyrene and oil.
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