Effect of Sulfonamide Compounds upon Staphylocoagulase. ∗

Abstract

Summary

1. Sulfathiazole and, to a slightly lesser extent, sulfanilamide accelerated the clotting action in citrated plasma of staphylocoagulase contained in a sterile broth filtrate. Sulfadiazine markedly inhibited the coagulating effect, while sulfapyridine had only slight inhibitory activity. 2. Para-aminobenzoic acid operated like sulfanilamide and accelerated the coagulating action. 3. Broth filtrates with staphylocoagulase did not cause coagulation of every sample of normal, citrated human plasma. The degree of coagulation also varied.