Abstract
Summary
1. Two samples of cozymase were tested, and each could replace both thiamin chloride and nicotinic acid, essential growth requirements for the staphylococcus; however, these preparations contained small quantities of thiamin. It has been shown that an adequate amount of thiamin was contained in the cozymase, which explains why maximum growth of staphylococci was obtained in the presence of cozymase, but in the absence of nicotinic acid. 2. When certain experimental conditions are fulfilled, cozymase, but not thiamin chloride and nicotinic acid, will inhibit the bacteriostatic action of sulfanilamide and sulfapyridine against staphylococci.
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