Abstract
Summary
Uterine and extragenital fibroids were elicited by subcutaneous administration of estradiol monobenzoate in castrate female guinea pigs weighing no more than 180 to 245 g at the beginning of treatment and autopsied 2 1/2 to 3 months later before they reached a body weight of 500 g. The incidence of abdominal fibroids in these young animals was no less than in a group of adult or aged animals weighing 700 to 1050 g at the beginning of treatment. Whereas this statement referring to the occurrence of experimental abdominal fibroids in young females seems definite, the question remains open whether age may influence the degree of the fibromatous reaction, i. e., size and number of fibroids.
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