Abstract
Summary
From the foregoing results it seems clear that in the dog, removal of both kidneys does not prevent the immediate appearance of a pressor response to moderator nerve section. The reflex response to such a procedure is at least equal to that seen in normal dogs and if anything, seems to be heightened. Chloralose and ether were each used as anesthetic agents in both groups of experiments. It so happened that one of the most marked pressor responses occurred after the use of each kind of anesthetic agent in both the normal and nephrectomized group of dogs. In view of the slightly different initial blood pressure levels in the two groups, as well as the difficulty in ascertaining the exact depth of anesthesia in each experiment, close quantitative comparison of the pressor responses in the two groups is not justified. It would seem, however. that circulating pressor substances arising from the kidney (e. g., angiotonin) are not demonstrably important in the production of acute neurogenic hypertension.
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