Abstract
Conclusions
An inflammatory exudate readily induces an increased capillary permeability as evidenced by the rapid accumulation of trypan blue from the circulation into cutaneous areas treated with the exudative material. Dialysis of the exudate allows the outward diffusion of leukotaxine. The indiffusible residual material remaining after dialysis of the exudate is essentially incapable of increasing capillary permeability with the characteristic homogeneous pattern. The exact original effect of the exudate, however, can be readily reconstituted by merely adding leukotaxine to the indiffusible fraction of the dialyzed exudate. This cannot be obtained by adding histamine in the concentration in which the latter is recovered from exudates. These facts therefore add further support to previous observations that leukotaxine and not histamine is the primary factor concerned in the mechanism of increased capillary permeability in inflammation.
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