Abstract
Summary
(1) The absorption of many drugs introduced into the bone marrow was studied in various animals. (2) Aqueous solutions of all such agents were rapidly absorbed as indicated by their characteristic systemic effects. (3) Intramedullar injections offer an especially useful means for pharmacological study of oils and oily solutions. (4) Volatile oils are rapidly absorbed through bone marrow but the fixed oils are absorbed more slowly, thus retarding absorption of active principles dissolved therein. (5) Epinephrine in oil, introduced into medullary canals, produces a marked and long-sustained rise in blood pressure, an effect which cannot be achieved by intramuscular injection of such an oil solution.
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