Abstract
Summary
Two hypotensive extracts, namely Padutin and tissue extract No. 568, advocated in the treatment of important circulatory disorders, produced no demonstrable changes in blood pressure and no symptoms after oral and intramuscular administrations in very high (beyond therapeutic) doses in animals. Placed directly into ligated intestinal loops, both extracts remained unchanged and unabsorbed for 2 hours. All the animals reacted typically to control intravenous injections of both extracts. A range of fatal doses was determined intravenously only in pigeons, because very much larger doses given either by the oral or intramuscular route were without demonstrable effects. An experimental basis for the clinical use of the “hypotensive” tissue extracts, either orally or intramuscularly, is completely lacking. However, accidental intravenous injections, resulting from careless intramuscular or hypodermic uses, could conceivably cause alarming symptoms and even death. These extracts are undesirable, if not dangerous, for intravenous use.
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