Thermostable Oxidations in Tumor and Muscle Tissue

Abstract

Summary

It has been shown that although minced Flexner-Jobling rat carcinoma has an aerobic respiration equal to that of rat skeletal muscle mince, the oxygen uptake in the presence of gluta-thione of thermostable powders (essentially denatured proteins) prepared from the tumor tissue is considerably lower than the oxygen uptake of similar powders prepared from muscle. This seems to parallel the fact that although the tumor powder and the muscle powder have approximately the same total sulfur content, the percent of the total sulfur which is present as sulfhydryl sulfur is much lower in the tumor powder than in the muscle powder.