Abstract
Conclusion
A change in the physiological activity of a nicotine solution accompanies a change in pH of the solution when the phenomenon of transport across membranes is involved. An increase in pH causes an increase in the proportion of free base present, and, as pointed out by Ellisor and Richardson, 1 an increase in the rate at which nicotine passes through membranes. This is believed to account for the fact that a solution containing equal parts of nicotine acetate and the free base is about three times more effective in inhibiting ciliary activity than a solution containing about 98% of the acetate.
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