Mechanism of Insulin Convulsions. III. Effects of Varying Partial Pressures of Atmospheric Gases After Adrenalectomy

Abstract

Conclusions

Anoxic anoxia (breathing 5% O₂ plus 95% N₂) causes hypoglycemia in adrenalectomized dogs without insulin in contrast to the hyperglycemia observed in normal animals. Insulin convulsions are prevented by anoxia of this degree even when the fall in blood sugar is maximal. Breathing 15% CO₂ likewise tends to prevent insulin convulsions from occurring.