Abstract
Summary
If the sodium salts of the two drugs be used, the toxicity of sulfathiazole appears to be about 65% of the toxicity of sulfapyridine for LD50. Repeated administration of the drugs in the food of mice indicates that sulfathiazole is more toxic than sulfapyridine at a high dose level but that there is no difference at a dose level which is effective therapeutically. In monkeys and growing rats, receiving either drug for 14-57 days, sulfapyridine is clearly the more toxic. The principal pathological change in all 3 species appears to be renal damage.
Metabolic studies indicate that sulfathiazole is more rapidly metabolized and undergoes much less conjugation than sulfapyridine.
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