Sulfanilamide and Sulfapyridine in Treatment of Experimental B. typhosus (Eberthella typhosus) Infections of Mice

Abstract

Summary

Sulfanilamide by subcutaneous injection in dose of 0.160 g per kilo apparently prolonged the lives of some mice when given in 2 doses 6 hours apart before intraperitoneal inoculation with B. typhosus in a dose fatal in about 48 hours, followed by subsequent doses at 6-hour intervals. But when the compound in the same dose was given by subcutaneous injection immediately after inoculation followed by subsequent doses at 6-hour intervals there was much less evidence of therapeutic activity. However, sulfanilamide was much more effective when given intraperitoneally in the same dose 2 hours after intraperitoneal inoculation followed by a second dose 4 hours later and subsequent doses at 6-hour intervals. Of the total of 22 treated mice in 3 experiments, 3 survived and the lives of 7 were prolonged, whereas all of 8 untreated controls succumbed in 1 to 2 days after inoculation.

Sulfapyridine was less effective. Of 10 mice given 0.160 g by intraperitoneal injection immediately after inoculation, followed by a second dose 4 hours later and subsequent doses at 6-hour intervals, one survived and the lives of 2 were prolonged about 24 hours beyond the survival of 4 untreated controls which succumbed in 24 to 48 hours after inoculation.