Abstract
Summary
Isomannide when administered orally to man or by vein to dogs is excreted unchanged in the urine in large quantities producing an increase in urine volume. Isomannide when ingested in large quantities or administered intravenously produced no toxic symptoms. Like urea, isomannide permeates the red blood cells eliciting the characteristic osmotic phenomena. The diuretic activity of isomannide is likely due to its lack of tubular absorption, thus increasing the osmotic pressure of the fluid upon which the water-absorbing cells are acting and thereby increasing the volume of urine excreted.
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