Relation of Reticulo-Endothelial System to Refractoriness Developed in Response to Gonadotropic Hormone

Abstract

Summary

1. Immature splenectomized rats injected with pregnancy urine extract for 20 days produce a smaller quantity of inhibitory substance than normal injected controls. 2. “Blockage” experiments with trypan blue indicate that the production of antagonistic principle is not peculiar to the spleen but is possessed by the reticuloendothelial system as a whole.