Abstract
Summary
It has lieen shown that the addition of a weakly alkaline, buffered solution of safranin to a solution of commercial insulin yields an insulin-containing precipitate which, when injected in suspension into animals, causes hypoglycemia of gradual onset and extended duration. The blood sugar curve so produced is similar to, but not quite so depressed as, that given by the injection of an equal amount of protamine insulin suspension. The redissolved precipitates of safranin and protamine insulin are considerably inferior to the suspensions in retarding the fall of the blood sugar and/or prolonging the period of hypoglycemia.
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