Abstract
Conclusion
At a pH of 7.4, concentrations of dinitrophenol from 1:5,000,000 to 1:20,000,000 slightly increased the rate of oxidation of alcohol by rat liver in vitro, while higher concentrations slightly diminished it. This indicated that under some conditions an increase in tissue metabolism produced by dinitrophenol is accompanied by an increased rate of oxidation of alcohol. From this it may be deduced that the increased rate of fall of blood alcohol concentration caused by dinitrophenol in animals may be accounted for, in part at least, by an increased rate of its oxidation in the tissues. Further work, both in vitro and in vivo, is in progress to investigate this problem more fully.
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