Abstract
It was shown 1 that in the completely depancreatized dog maintained with insulin the blood lipids were markedly reduced. The most pronounced change occurred in the cholesterol, the esterified portion of which was either completely absent or present to the extent of 2–7% of the total cholesterol. The present report deals with the effects of the ingestion of raw pancreas upon blood lipids. It was found that the addition twice daily of 125 gm. of the gland to the diet of the dogs soon after pancreatectomy not only prevented the drop but led to a significant rise above normal in all lipid constituents. In these animals the blood lipids could be made to fluctuate by the addition or removal of the glandular tissue in the diet. The constituent affected to the greatest degree by the ingestion of the pancreas was esterified cholesterol, whereas free cholesterol showed the least change. A typical result is shown in Table I. Following the second removal of raw pancreas from the diet, the esterified cholesterol decreased but did not completely disappear from the blood despite the fact that no pancreas was ingested for a period of 78 days.
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