Abstract
The anterior hypophysis has been shown to be related to carbohydrate metabolism by the studies of Houssay and Biasotti 1 in which the acute diabetes induced by pancreatectomy, in the dog, was relieved by removal of the anterior hypophysis. In a study based on the recognized action of oestrin in suppressing the anterior lobe it was shown by one of us 2 that administration of oestrin in depan-creatized dogs had much the same effect as removal of the hypophysis.
Repetition and extension of this work on a form more closely related to man was believed to be of some importance. Accordingly we have employed the rhesus monkey in a series of experiments designed not only to repeat the studies on the dog, but also to gather data concerning the physiological mechanisms involved, and to determine the effect of continued oestrin administration, in depan-creatized animals, upon certain other organs. At this time we are reporting the results of experiments conducted on 6 immature female monkeys (3 to 3.5 kg. in weight).
In 2 animals the injection of an acid extract of beef hypophyses 2 has induced hyperglycemia and glycosuria. We have used, uniformly, the Shaffer-Somogyi 3 method for sugar determination and have determined the true sugar as well as total reducing substances in both blood and urine. Twenty-four hour collections of urine were made regularly.
Four animals have been depancreatized. In 2 cases a small fragment of pancreas was not removed. In the remaining 2 animals pancreatectomy is believed to have been complete.
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