Abstract
Conclusion
Since dinitrophenol is unable to oxidize such a labile compound as lactate activated by a-hydroxyoxidase; is without effect Lvhen the respiration of cells and tissues has been inhibited by cyanide or carbon monoxide; and has no action on the respiration of certain bacteria, where the complicated controlling mechanisms present in highly organized cells are absent, it is concluded that the increase in respiration produced by dinitrophenol is not due to direct oxidation of the oxidizable substrates. It is suggested that dinitrophenol acts by combining with some of the substances acting as agents for the control of the speed of cellular oxidations, thus increasing the activity of the oxidizing enzymes.
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