Abstract
Ochsner and Garside 1 reported the results of their studies on the effect of intravenous injection of 20 different sclerosing solutions. This paper is a report of the continuation of that work, comprising a similar study of 9 additional solutions.
Method. The methods used were the same as those previously employed. Eighteen dogs were used, and 4 injections were made at different levels in the veins of each leg, thus making 16 injections of a sclerosing substance in each dog. Only one drug was used for each leg, but different drugs were sometimes injected into each leg of the animal. Five-tenths cc. of each of the following solutions were injected into 16 veins:
The area of injection was marked and subsequently the veins were cautiously removed under local anesthesia to prevent the dislodgement of thrombi. The more distal segments of vein were removed first.
Sections were removed at the following intervals: 1/2, 1, 3, 6, 12, 24, and 48 hr., 3, 4, 6, 10, 14, 21 days, 4, 6, and 8 weeks. Thus, there were 16 sections studied for each solution.
After removal the veins were prepared for microscopic study by staining with hematoxylin and eosin and Mallory's connective tissue stains. Some sections were stained by Werhoff's elastic tissue method.
Thrombus Production. Searle's sodium morrhuate produced thrombosis in the greatest numper of instances, 71.4% of the veins, sodium gynocardate (5%) in 50%, sodium gynocardate (3%) in 50%, sodium gynocardate (2%) in 44%, sodium hydnocarpate (5%) in 37.5%, sodium |morrhuate (own, 5%) in 33%, sodium hydnocarpate (3%) in 33%, sodium morrhuate (10%) in 19%, and sodium hydnocarpate (2%) in 12.5%.
As the methods used were the same and as one∗ of us studied the sections in each series, our results may be compared with those of Ochsner and Garside.
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