Picrotoxin-Stramonium Antagonism

Abstract

Conclusions

1. Stramonium exhibits an antagonistic action toward the convulsant stimulation of picrotoxin in rats. 2. The antagonistic action of stramonium is limited by an evident stimulant effect in large doses upon the central nervous system. 3. It is suggested that the stimulant action of stramonium in large doses upon the central nervous system may be, in part at least, an explanation of the therapeutic value of stramonium upon the partially destroyed cells of the substantia nigra, in the large doses found desirable in Parkinsonism. 4. There is a possibility that the picrotoxin-stra-monium antagonism might serve as a means of the biological standardization of stramonium.