Abstract
In the preceding note we have called attention to certain periodic leukocytic fluctuations which occur simultaneously in all normal individuals as well as patients.
If we analyze the differential count the leukocytic partition reveals even more clearly the periods of stimulation, both in the increase in the number of polymorphonuclear leukocytes as well as the striking periodicity in the appearance of the eosinophiles. In the normal individual this eosinophilia is limited to 2 or 3% of the total count, in the vegetatively stigmatized group of individuals, however, the count may reach 15% on such days of stimulation with a complete disappearance the following day. It is, of course, well known that the periods of stimulation apparent in the patient with pernicious anemia are heralded by a similar increase in the eosinophile count.
In the graphic presentation of the same 4 normal subjects discussed in the preceding note, a barographic tracing has been carried across the chart for each individual subject (heavy line) and the daily percentage of polymorphs is indicated in a light solid line. The number of eosinophiles is indicated by the small crosses below the barograph and basophiles are indicated by the letter B. They were only observed in subject No. 2.
It will be noted that (1) subject No. 4 has the lowest proportion of polymorphonuclear leukocytes and in this individual the periods of stimulation and recovery are of longer duration and of somewhat greater magnitude. (2) The periods of stimulation occur synchronously in all the individuals. (3) That these periods are associated with the appearance of eosinophiles so that these, too, occur simultaneously in all individuals.(3) That these periods are associated with the appearance of eosinophiles so that these, too, occur simultaneously in all individuals.
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