Abstract
Summary
Pituitrin and pilocarpine have been administered to dogs by various routes and under various conditions. Intraventricular pituitrin in unanesthetized animals resulted in a fall in body temperature in the majority of cases, usually 0.6° or more, in distinct salivation, and in several instances in stimulation of the smooth muscle of the gastro-intestinal tract resulting in retching, vomiting or evacuation of the bowel. In animals anesthetized with chloralose there was less regularity in the effects produced, possibly because the anesthetic acts on the same centers as pituitrin.
Pilocarpine intraveiitricularly in unanesthetized dogs resulted in a rise in temperature and profuse salivation as did intramuscular pilocarpine. Gastro-intestinal effects occurred more frequently after intramuscular and subcutaneous pilocarpine than after intraventricular injection.
When these results are compared with those on man, it is evident that they are less conclusive and reveal marked differences in the reactions of man and dog to the effect of pituitrin and pilocarpine when introduced into the ventricles.
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